The main purpose of the Knock Out Cancer Act is to increase funding for cancer research through the National Cancer Institute (NCI). The goal is to ensure that funding levels are more closely aligned with the mortality rates associated with cancer, which is a leading cause of death in the United States. Key provisions of the Act include a significant increase in the budget for cancer research. Specifically, for each fiscal year from 2026 to 2030, the NCI will receive an amount equal to 25 percent of what was appropriated for the NCI in fiscal year 2022.